GPR30 receptor promotes preoperative anxiety-induced postoperative hyperalgesia by up-regulating GABA<sub>A</sub>-&#945;4ß1Î´ subunits in periaqueductal gray in female rats.

Jiang, Ming; Sun, Yu'e; Lei, Yishan; Hu, Fan; Xia, Zhengrong; Liu, Yue; Ma, Zhengliang; Gu, Xiaoping

GPR30 receptor promotes preoperative anxiety-induced postoperative hyperalgesia by up-regulating GABA_A-α4ß1Î´ subunits in periaqueductal gray in female rats.

Jiang, Ming; Sun, Yu'e; Lei, Yishan; Hu, Fan; Xia, Zhengrong; Liu, Yue; Ma, Zhengliang; Gu, Xiaoping.

Afiliação

Jiang M; Department of Anesthesiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, Jiangsu Province, China.
Sun Y; Department of Anesthesiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, Jiangsu Province, China.
Lei Y; Department of Anesthesiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, Jiangsu Province, China.
Hu F; Analytical & Testing Center, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Xia Z; Analytical & Testing Center, Nanjing Medical University, Nanjing, Jiangsu Province, China.
Liu Y; Department of Anesthesiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, Jiangsu Province, China.
Ma Z; Department of Anesthesiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, Jiangsu Province, China.
Gu X; Department of Anesthesiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, 210008, Jiangsu Province, China. doctorgxp@163.com.

BMC Anesthesiol ; 20(1): 93, 2020 04 22.

Article em En | MEDLINE | ID: mdl-32321426

Assuntos

Ansiedade/fisiopatologia; Dor Pós-Operatória/fisiopatologia; Receptores Acoplados a Proteínas G/metabolismo; Receptores de GABA-A/genética; Animais; Ansiedade/complicações; Benzodioxóis/farmacologia; Modelos Animais de Doenças; Feminino; Hiperalgesia/fisiopatologia; Substância Cinzenta Periaquedutal/metabolismo; Período Pré-Operatório; Quinolinas/farmacologia; Ratos; Ratos Sprague-Dawley; Regulação para Cima

Palavras-chave

Female rat; GABAA-α4ß1Î´ subunits; GPR30 receptor; Postoperative hyperalgesia; Preoperative anxiety

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ansiedade / Dor Pós-Operatória / Receptores de GABA-A / Receptores Acoplados a Proteínas G Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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