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Serine mutation of a conserved threonine in the hERG K+ channel S6-pore region leads to loss-of-function through trafficking impairment.
Al-Moubarak, Ehab; Zhang, Yihong; Dempsey, Christopher E; Zhang, Henggui; Harmer, Stephen C; Hancox, Jules C.
Afiliação
  • Al-Moubarak E; School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK.
  • Zhang Y; School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK.
  • Dempsey CE; School of Biochemistry, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK.
  • Zhang H; Biological Physics Group, School of Physics and Astronomy, The University of Manchester, Manchester, M13 9PL, UK.
  • Harmer SC; School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK. Electronic address: s.c.harmer@bristol.ac.uk.
  • Hancox JC; School of Physiology, Pharmacology and Neuroscience, Biomedical Sciences Building, University Walk, Bristol, BS8 1TD, UK. Electronic address: jules.hancox@bristol.ac.uk.
Biochem Biophys Res Commun ; 526(4): 1085-1091, 2020 06 11.
Article em En | MEDLINE | ID: mdl-32321643
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Serina / Treonina / Sequência Conservada / Canal de Potássio ERG1 / Mutação com Perda de Função Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Serina / Treonina / Sequência Conservada / Canal de Potássio ERG1 / Mutação com Perda de Função Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article