Gut Microbiota and Neurologic Diseases and Injuries.
Adv Exp Med Biol
; 1238: 73-91, 2020.
Article
em En
| MEDLINE
| ID: mdl-32323181
ABSTRACT
The brain-gut axis is a bidirectional communication pathway connecting the central nervous system (CNS) and the gastrointestinal tract via nerve transmission, hormone, immune system, and other molecular signals. The bacterial flora of the human gut contributes direct and indirect signals to the CNS along the brain-gut axis. Alterations in gut flora, a state known as dysbiosis, has been tied to systemic inflammation, increased bacterial translocation, and increased absorbance of microbial by-products. An increase in recent literature has highlighted the role of the gut-brain axis in CNS pathology. This chapter reviews the association between gut flora dysbiosis and disorders of the central nervous system including autoimmune disease, developmental disorders, physiologic response to traumatic injury, and neurodegenerative disease.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Encefalopatias
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Doenças Neurodegenerativas
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Disbiose
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Microbioma Gastrointestinal
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article