The Swing of Lipids at Peroxisomes and Endolysosomes in T Cell Activation.
Int J Mol Sci
; 21(8)2020 Apr 19.
Article
em En
| MEDLINE
| ID: mdl-32325900
ABSTRACT
The immune synapse (IS) is a well-known intercellular communication platform, organized at the interphase between the antigen presenting cell (APC) and the T cell. After T cell receptor (TCR) stimulation, signaling from plasma membrane proteins and lipids is amplified by molecules and downstream pathways for full synapse formation and maintenance. This secondary signaling event relies on intracellular reorganization at the IS, involving the cytoskeleton and components of the secretory/recycling machinery, such as the Golgi apparatus and the endolysosomal system (ELS). T cell activation triggers a metabolic reprogramming that involves the synthesis of lipids, which act as signaling mediators, and an increase of mitochondrial activity. Then, this mitochondrial activity results in elevated reactive oxygen species (ROS) production that may lead to cytotoxicity. The regulation of ROS levels requires the concerted action of mitochondria and peroxisomes. In this review, we analyze this reprogramming and the signaling implications of endolysosomal, mitochondrial, peroxisomal, and lipidic systems in T cell activation.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Endossomos
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Ativação Linfocitária
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Linfócitos T
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Peroxissomos
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Metabolismo dos Lipídeos
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Lisossomos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article