Conjugated linoleic acid attenuates 2,4-dinitrofluorobenzene-induced atopic dermatitis in mice through dual inhibition of COX-2/5-LOX and TLR4/NF-&#954;B signaling.

Tang, Liu; Li, Xiao-Lei; Deng, Zi-Xin; Xiao, Yao; Cheng, Ya-Hong; Li, Jing; Ding, Hong

Conjugated linoleic acid attenuates 2,4-dinitrofluorobenzene-induced atopic dermatitis in mice through dual inhibition of COX-2/5-LOX and TLR4/NF-κB signaling.

Tang, Liu; Li, Xiao-Lei; Deng, Zi-Xin; Xiao, Yao; Cheng, Ya-Hong; Li, Jing; Ding, Hong.

Afiliação

Tang L; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei, PR China.
Li XL; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei, PR China.
Deng ZX; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei, PR China.
Xiao Y; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei, PR China.
Cheng YH; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei, PR China.
Li J; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei, PR China.
Ding H; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, School of Pharmaceutical Sciences, Wuhan University, Wuhan, Hubei, PR China. Electronic address: dinghong1106@whu.edu.cn.

J Nutr Biochem ; 81: 108379, 2020 07.

Article em En | MEDLINE | ID: mdl-32330842

Assuntos

Anti-Inflamatórios/farmacologia; Dermatite Atópica/tratamento farmacológico; Dinitrofluorbenzeno/efeitos adversos; Ácidos Linoleicos Conjugados/farmacologia; Animais; Anti-Inflamatórios/administração & dosagem; Araquidonato 5-Lipoxigenase/metabolismo; Ciclo-Oxigenase 2/metabolismo; Citocinas/sangue; Dermatite Atópica/induzido quimicamente; Dermatite Atópica/metabolismo; Dinoprostona/metabolismo; Humanos; Leucotrieno B4/metabolismo; Ácidos Linoleicos Conjugados/administração & dosagem; Masculino; Mastócitos/metabolismo; Camundongos; Fator 88 de Diferenciação Mieloide/metabolismo; NF-kappa B/metabolismo; Transdução de Sinais/efeitos dos fármacos; Pele/efeitos dos fármacos; Pele/patologia; Receptor 4 Toll-Like/metabolismo; Fator de Necrose Tumoral alfa/metabolismo

Palavras-chave

2, 4-Dinitrofluorobenzene; Atopic dermatitis; Conjugated linoleic acid; Inflammation; Mice

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ácidos Linoleicos Conjugados / Dermatite Atópica / Dinitrofluorbenzeno / Anti-Inflamatórios Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google