Therapeutic Efficacy of Immune Stimulatory Thymidine Kinase and fms-like Tyrosine Kinase 3 Ligand (TK/Flt3L) Gene Therapy in a Mouse Model of High-Grade Brainstem Glioma.

Mendez, Flor; Kadiyala, Padma; Nunez, Felipe J; Carney, Stephen; Nunez, Fernando M; Gauss, Jessica C; Ravindran, Ramya; Pawar, Sheeba; Edwards, Marta; Garcia-Fabiani, Maria Belen; Haase, Santiago; Lowenstein, Pedro R; Castro, Maria G

Mendez, Flor; Kadiyala, Padma; Nunez, Felipe J; Carney, Stephen; Nunez, Fernando M; Gauss, Jessica C; Ravindran, Ramya; Pawar, Sheeba; Edwards, Marta; Garcia-Fabiani, Maria Belen; Haase, Santiago; Lowenstein, Pedro R; Castro, Maria G.

Afiliação

Mendez F; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan.
Kadiyala P; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan.
Nunez FJ; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan.
Carney S; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan.
Nunez FM; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan.
Gauss JC; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan.
Ravindran R; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan.
Pawar S; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan.
Edwards M; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan.
Garcia-Fabiani MB; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan.
Haase S; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan.
Lowenstein PR; Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan.
Castro MG; Department of Neurosurgery, University of Michigan Medical School, Ann Arbor, Michigan.

Clin Cancer Res ; 26(15): 4080-4092, 2020 08 01.

Article em En | MEDLINE | ID: mdl-32332014

Assuntos

Neoplasias do Tronco Encefálico/terapia; Terapia Genética/métodos; Vetores Genéticos/administração & dosagem; Glioma/terapia; Imunoterapia/métodos; Receptores de Ativinas Tipo I/genética; Animais; Neoplasias do Tronco Encefálico/genética; Neoplasias do Tronco Encefálico/imunologia; Neoplasias do Tronco Encefálico/patologia; Modelos Animais de Doenças; Feminino; Vetores Genéticos/genética; Glioma/genética; Glioma/imunologia; Glioma/patologia; Humanos; Masculino; Proteínas de Membrana/genética; Camundongos; Camundongos Transgênicos; Mutação; Ponte/patologia; Cultura Primária de Células; RNA-Seq; Transdução de Sinais/genética; Transdução de Sinais/imunologia; Esferoides Celulares; Timidina Quinase/genética; Fator de Crescimento Transformador beta/metabolismo; Células Tumorais Cultivadas/transplante; Microambiente Tumoral/genética; Microambiente Tumoral/imunologia

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Terapia Genética / Neoplasias do Tronco Encefálico / Vetores Genéticos / Glioma / Imunoterapia Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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