Your browser doesn't support javascript.
loading
The phylogenetic landscape and nosocomial spread of the multidrug-resistant opportunist Stenotrophomonas maltophilia.
Gröschel, Matthias I; Meehan, Conor J; Barilar, Ivan; Diricks, Margo; Gonzaga, Aitor; Steglich, Matthias; Conchillo-Solé, Oscar; Scherer, Isabell-Christin; Mamat, Uwe; Luz, Christian F; De Bruyne, Katrien; Utpatel, Christian; Yero, Daniel; Gibert, Isidre; Daura, Xavier; Kampmeier, Stefanie; Rahman, Nurdyana Abdul; Kresken, Michael; van der Werf, Tjip S; Alio, Ifey; Streit, Wolfgang R; Zhou, Kai; Schwartz, Thomas; Rossen, John W A; Farhat, Maha R; Schaible, Ulrich E; Nübel, Ulrich; Rupp, Jan; Steinmann, Joerg; Niemann, Stefan; Kohl, Thomas A.
Afiliação
  • Gröschel MI; Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.
  • Meehan CJ; Department of Pulmonary Diseases & Tuberculosis, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Barilar I; School of Chemistry and Bioscience, University of Bradford, Bradford, United Kingdom.
  • Diricks M; Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.
  • Gonzaga A; bioMérieux, Applied Maths NV, Keistraat 120, 9830, St-Martens-Latem, Belgium.
  • Steglich M; Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.
  • Conchillo-Solé O; Leibniz Institute DSMZ - German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.
  • Scherer IC; Institute of Biotechnology and Biomedicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Mamat U; Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Luz CF; Department of Infectious Diseases and Microbiology, University Hospital Schleswig-Holstein, Lübeck, Germany.
  • De Bruyne K; Cellular Microbiology, Research Center Borstel, Borstel, Germany.
  • Utpatel C; Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Yero D; bioMérieux, Applied Maths NV, Keistraat 120, 9830, St-Martens-Latem, Belgium.
  • Gibert I; Molecular and Experimental Mycobacteriology, Research Center Borstel, Borstel, Germany.
  • Daura X; Institute of Biotechnology and Biomedicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Kampmeier S; Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Rahman NA; Institute of Biotechnology and Biomedicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Kresken M; Department of Genetics and Microbiology, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • van der Werf TS; Institute of Biotechnology and Biomedicine, Universitat Autònoma de Barcelona, Barcelona, Spain.
  • Alio I; Catalan Institution for Research and Advanced Studies, Barcelona, Spain.
  • Streit WR; Institute of Hygiene, University Hospital Münster, Münster, Germany.
  • Zhou K; Department of Microbiology, Singapore General Hospital, Singapore, Singapore.
  • Schwartz T; Antiinfectives Intelligence GmbH, Rheinbach, Germany.
  • Rossen JWA; Rheinische Fachhochschule Köln gGmbH, Cologne, Germany.
  • Farhat MR; Department of Pulmonary Diseases & Tuberculosis, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Schaible UE; Department of Microbiology and Biotechnology, University of Hamburg, Hamburg, Germany.
  • Nübel U; Department of Microbiology and Biotechnology, University of Hamburg, Hamburg, Germany.
  • Rupp J; Shenzhen Institute of Respiratory Diseases, the First Affiliated Hospital (Shenzhen People's Hospital), Southern University of Science and Technology, Shenzhen, China.
  • Steinmann J; Second Clinical Medical College, Jinan University, Shenzhen, China.
  • Niemann S; Karlsruhe Institute of Technology, Institute of Functional Interfaces, Eggenstein- Leopoldshafen, Germany.
  • Kohl TA; Department of Medical Microbiology and Infection Prevention, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Nat Commun ; 11(1): 2044, 2020 04 27.
Article em En | MEDLINE | ID: mdl-32341346
ABSTRACT
Recent studies portend a rising global spread and adaptation of human- or healthcare-associated pathogens. Here, we analyse an international collection of the emerging, multidrug-resistant, opportunistic pathogen Stenotrophomonas maltophilia from 22 countries to infer population structure and clonality at a global level. We show that the S. maltophilia complex is divided into 23 monophyletic lineages, most of which harbour strains of all degrees of human virulence. Lineage Sm6 comprises the highest rate of human-associated strains, linked to key virulence and resistance genes. Transmission analysis identifies potential outbreak events of genetically closely related strains isolated within days or weeks in the same hospitals.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Bactérias Gram-Negativas / Stenotrophomonas maltophilia / Farmacorresistência Bacteriana Múltipla / Antibacterianos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Bactérias Gram-Negativas / Stenotrophomonas maltophilia / Farmacorresistência Bacteriana Múltipla / Antibacterianos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article