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Feasibility of blood testing combined with PET-CT to screen for cancer and guide intervention.
Lennon, Anne Marie; Buchanan, Adam H; Kinde, Isaac; Warren, Andrew; Honushefsky, Ashley; Cohain, Ariella T; Ledbetter, David H; Sanfilippo, Fred; Sheridan, Kathleen; Rosica, Dillenia; Adonizio, Christian S; Hwang, Hee Jung; Lahouel, Kamel; Cohen, Joshua D; Douville, Christopher; Patel, Aalpen A; Hagmann, Leonardo N; Rolston, David D; Malani, Nirav; Zhou, Shibin; Bettegowda, Chetan; Diehl, David L; Urban, Bobbi; Still, Christopher D; Kann, Lisa; Woods, Julie I; Salvati, Zachary M; Vadakara, Joseph; Leeming, Rosemary; Bhattacharya, Prianka; Walter, Carroll; Parker, Alex; Lengauer, Christoph; Klein, Alison; Tomasetti, Cristian; Fishman, Elliot K; Hruban, Ralph H; Kinzler, Kenneth W; Vogelstein, Bert; Papadopoulos, Nickolas.
Afiliação
  • Lennon AM; Department of Oncology, the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
  • Buchanan AH; The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
  • Kinde I; Department of Medicine Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
  • Warren A; Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
  • Honushefsky A; Thrive Earlier Detection Corp., 38 Sidney Street Cambridge, MA 02139, USA.
  • Cohain AT; Thrive Earlier Detection Corp., 38 Sidney Street Cambridge, MA 02139, USA.
  • Ledbetter DH; Third Rock Ventures, LLC, 29 Newbury Street Boston, MA 02116, USA.
  • Sanfilippo F; Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
  • Sheridan K; Thrive Earlier Detection Corp., 38 Sidney Street Cambridge, MA 02139, USA.
  • Rosica D; Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
  • Adonizio CS; Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 100 Woodruff Circle Atlanta, GA 30322, USA.
  • Hwang HJ; Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
  • Lahouel K; Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
  • Cohen JD; Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
  • Douville C; Geisinger Cancer Institute, 100 N. Academy Avenue Danville, PA 17822, USA.
  • Patel AA; Thrive Earlier Detection Corp., 38 Sidney Street Cambridge, MA 02139, USA.
  • Hagmann LN; Department of Oncology, the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
  • Rolston DD; Division of Biostatistics and Bioinformatics, Department of Oncology, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
  • Malani N; Department of Oncology, the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
  • Zhou S; The Sol Goldman Pancreatic Cancer Research Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
  • Bettegowda C; The Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
  • Diehl DL; The Ludwig Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
  • Urban B; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
  • Still CD; Department of Oncology, the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
  • Kann L; The Ludwig Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
  • Woods JI; Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
  • Salvati ZM; Thrive Earlier Detection Corp., 38 Sidney Street Cambridge, MA 02139, USA.
  • Vadakara J; Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
  • Leeming R; Thrive Earlier Detection Corp., 38 Sidney Street Cambridge, MA 02139, USA.
  • Bhattacharya P; Department of Oncology, the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
  • Walter C; The Ludwig Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
  • Parker A; Department of Oncology, the Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
  • Lengauer C; The Ludwig Center, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
  • Klein A; Department of Neurosurgery, Johns Hopkins University School of Medicine, 733 N. Broadway, Baltimore, MD 21205, USA.
  • Tomasetti C; Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
  • Fishman EK; Thrive Earlier Detection Corp., 38 Sidney Street Cambridge, MA 02139, USA.
  • Hruban RH; Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
  • Kinzler KW; Thrive Earlier Detection Corp., 38 Sidney Street Cambridge, MA 02139, USA.
  • Vogelstein B; Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
  • Papadopoulos N; Geisinger, 100 N. Academy Avenue Danville, PA 17822, USA.
Science ; 369(6499)2020 07 03.
Article em En | MEDLINE | ID: mdl-32345712
Cancer treatments are often more successful when the disease is detected early. We evaluated the feasibility and safety of multicancer blood testing coupled with positron emission tomography-computed tomography (PET-CT) imaging to detect cancer in a prospective, interventional study of 10,006 women not previously known to have cancer. Positive blood tests were independently confirmed by a diagnostic PET-CT, which also localized the cancer. Twenty-six cancers were detected by blood testing. Of these, 15 underwent PET-CT imaging and nine (60%) were surgically excised. Twenty-four additional cancers were detected by standard-of-care screening and 46 by neither approach. One percent of participants underwent PET-CT imaging based on false-positive blood tests, and 0.22% underwent a futile invasive diagnostic procedure. These data demonstrate that multicancer blood testing combined with PET-CT can be safely incorporated into routine clinical care, in some cases leading to surgery with intent to cure.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Programas de Rastreamento / Detecção Precoce de Câncer / Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada / Testes Hematológicos / Neoplasias Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Aged / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Programas de Rastreamento / Detecção Precoce de Câncer / Tomografia por Emissão de Pósitrons combinada à Tomografia Computadorizada / Testes Hematológicos / Neoplasias Tipo de estudo: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Aged / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article