Investigating APOE, APP-Aß metabolism genes and Alzheimer's disease GWAS hits in brain small vessel ischemic disease.

Blumenau, Sonja; Foddis, Marco; Müller, Susanne; Holtgrewe, Manuel; Bentele, Kajetan; Berchtold, Daniel; Beule, Dieter; Dirnagl, Ulrich; Sassi, Celeste

Blumenau, Sonja; Foddis, Marco; Müller, Susanne; Holtgrewe, Manuel; Bentele, Kajetan; Berchtold, Daniel; Beule, Dieter; Dirnagl, Ulrich; Sassi, Celeste.

Afiliação

Blumenau S; Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Foddis M; Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Müller S; Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Holtgrewe M; Berlin Institute of Health, BIH, Core Unit Bioinformatics, Berlin, Germany.
Bentele K; Berlin Institute of Health, BIH, Core Unit Bioinformatics, Berlin, Germany.
Berchtold D; Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Beule D; Berlin Institute of Health, BIH, Core Unit Bioinformatics, Berlin, Germany.
Dirnagl U; Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Sassi C; Department of Experimental Neurology, Center for Stroke Research Berlin (CSB), Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany. celeste.sassi@charite.de.

Sci Rep ; 10(1): 7103, 2020 04 28.

Article em En | MEDLINE | ID: mdl-32345996

Assuntos

Alelos; Doença de Alzheimer; Precursor de Proteína beta-Amiloide; Apolipoproteínas E; Isquemia Encefálica; Encéfalo; Loci Gênicos; Idoso; Doença de Alzheimer/genética; Doença de Alzheimer/metabolismo; Doença de Alzheimer/patologia; Doença de Alzheimer/fisiopatologia; Precursor de Proteína beta-Amiloide/genética; Precursor de Proteína beta-Amiloide/metabolismo; Animais; Apolipoproteínas E/genética; Encéfalo/irrigação sanguínea; Encéfalo/metabolismo; Encéfalo/patologia; Isquemia Encefálica/genética; Isquemia Encefálica/metabolismo; Isquemia Encefálica/patologia; Isquemia Encefálica/fisiopatologia; Modelos Animais de Doenças; Feminino; Estudo de Associação Genômica Ampla; Humanos; Masculino; Camundongos; Camundongos Transgênicos; Pessoa de Meia-Idade

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apolipoproteínas E / Encéfalo / Isquemia Encefálica / Precursor de Proteína beta-Amiloide / Alelos / Loci Gênicos / Doença de Alzheimer Limite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google