Your browser doesn't support javascript.
loading
Probiotic strain Lactobacillus plantarum YYC-3 prevents colon cancer in mice by regulating the tumour microenvironment.
Yue, Yuanchun; Ye, Kai; Lu, Jing; Wang, Xinyu; Zhang, Shuwen; Liu, Liu; Yang, Baoyu; Nassar, Khaled; Xu, Xiaoxi; Pang, Xiaoyang; Lv, Jiaping.
Afiliação
  • Yue Y; College of Food Science, Northeast Agricultural University, Harbin, 150030, PR China; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, 100193, PR China. Electronic address: yueyuanchungreat@163.com.
  • Ye K; Department of Radiology, Peking University Third Hospital, Beijing, PR China. Electronic address: yekaibysy@bjmu.edu.cn.
  • Lu J; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, 100193, PR China. Electronic address: lujing@caas.cn.
  • Wang X; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, PR China. Electronic address: wangxinyu@ibp.ac.cn.
  • Zhang S; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, 100193, PR China. Electronic address: zhangshuwen@caas.cn.
  • Liu L; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, 100193, PR China. Electronic address: liuliuwur@126.com.
  • Yang B; College of Food Science, Northeast Agricultural University, Harbin, 150030, PR China. Electronic address: youngby2012@163.com.
  • Nassar K; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, 100193, PR China. Electronic address: Khalid.nassar@agr.dmu.edu.eg.
  • Xu X; College of Food Science, Northeast Agricultural University, Harbin, 150030, PR China. Electronic address: xiaoxi_xu01@163.com.
  • Pang X; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, 100193, PR China. Electronic address: pangxiaoyang@163.com.
  • Lv J; Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing, 100193, PR China. Electronic address: lvjiapingcaas@126.com.
Biomed Pharmacother ; 127: 110159, 2020 Jul.
Article em En | MEDLINE | ID: mdl-32353824
The gut microbiota plays important roles in chronic inflammation and colon cancer. Lactobacillus is a gut-resident probiotic with benefits to host health. We recently identified Lactobacillus plantarum strain YYC-3 with strong inhibition against two colon cancer cell lines (HT-29 and Caco2). However, the inhibitory effect of YYC-3 against colon cancer in vivo has not been verified. Thus, in the present study, we explored the probiotic function of strain YYC-3 and its cell-free supernatant (YYCS) respectively in the APCMin/+ mouse model of colon cancer during tumour development and growth, and the underlying anti-cancer mechanism. Treatment of both strain YYC-3 and the YYCS prevented the occurrence of colon tumours and mucosal damage in APCMin/+ mice fed a high-fat diet, although YYC-3 had a stronger anti-cancer effect. The mechanism involved modulation of the immune system and downregulated expression of the inflammatory cytokines interleukin (IL)-6, IL-17 F, and IL-22, along with reduced infiltration of inflammatory cells. Moreover, YYC-3 suppressed activation of the NF-κB and Wnt signalling pathways, and restored the altered gut microbiota composition to closely match that of wild-type mice. These results lay a theoretical foundation for application of YYC-3 in colon cancer prevention.
Assuntos
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Colo / Probióticos / Lactobacillus plantarum / Microambiente Tumoral Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Colo / Probióticos / Lactobacillus plantarum / Microambiente Tumoral Tipo de estudo: Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article