Design, synthesis and acaricidal activities of Cyflumetofen analogues based on carbon-silicon isosteric replacement.

Zhou, Cong; Cheng, Jiagao; Beadle, Ryan; Earley, Fergus G; Li, Zhong; Maienfisch, Peter

Zhou, Cong; Cheng, Jiagao; Beadle, Ryan; Earley, Fergus G; Li, Zhong; Maienfisch, Peter.

Afiliação

Zhou C; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Cheng J; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China. Electronic address: jgcheng@ecust.edu.cn.
Beadle R; Syngenta Crop Protection AG, Jealott's Hill Research Centre, Bracknell, Berkshire, UK; Department of Biochemistry, University of York, UK.
Earley FG; Syngenta Crop Protection AG, Jealott's Hill Research Centre, Bracknell, Berkshire, UK.
Li Z; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
Maienfisch P; Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China; Syngenta Crop Protection AG, Schwarzwaldallee 215, CH-4002 Basel, Switzerland. Electronic address: peter.maienfisch@syngenta.com.

Bioorg Med Chem ; 28(11): 115509, 2020 06 01.

Article em En | MEDLINE | ID: mdl-32354673

Assuntos

Acaricidas/farmacologia; Carbono/química; Desenho de Fármacos; Complexo II de Transporte de Elétrons/antagonistas & inibidores; Inibidores Enzimáticos/farmacologia; Propionatos/farmacologia; Silício/química; Acaricidas/síntese química; Acaricidas/química; Animais; Cianatos/farmacologia; Relação Dose-Resposta a Droga; Complexo II de Transporte de Elétrons/metabolismo; Inibidores Enzimáticos/síntese química; Inibidores Enzimáticos/química; Estrutura Molecular; Propionatos/química; Relação Estrutura-Atividade; Tetranychidae/enzimologia

Palavras-chave

Beta-ketonitrile acaricide; Carbon-silicon bioisosteric replacement; Discovery of Sila-Cyflumetofen; Homology model; Spider mite SQR inhibition; Succinate ubiquinone oxidoreductase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Propionatos / Silício / Carbono / Desenho de Fármacos / Complexo II de Transporte de Elétrons / Inibidores Enzimáticos / Acaricidas Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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