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Time-trend population analysis of the clinical and epidemiologic effect on pediatric infective endocarditis after change of antibiotic prophylaxis guidelines.
Knirsch, Walter; Schuler, Stefanie Katharina; Christmann, Martin; Weber, Roland.
Afiliação
  • Knirsch W; Children's Research Center, Zurich, Switzerland. walter.knirsch@kispi.uzh.ch.
  • Schuler SK; Pediatric Cardiology, Department of Surgery, Pediatric Heart Center, University Children's Hospital, Steinwiesstrasse 75, CH-8032, Zurich, Switzerland. walter.knirsch@kispi.uzh.ch.
  • Christmann M; Children's Research Center, Zurich, Switzerland.
  • Weber R; Pediatric Cardiology, Department of Surgery, Pediatric Heart Center, University Children's Hospital, Steinwiesstrasse 75, CH-8032, Zurich, Switzerland.
Infection ; 48(5): 671-678, 2020 Oct.
Article em En | MEDLINE | ID: mdl-32356253
ABSTRACT

PURPOSE:

In 2007, antibiotic prophylaxis (AP) guidelines for infective endocarditis (IE) changed, but the possible influence on the annual incidences of pediatric IE is unclear.

METHODS:

We studied the clinical and epidemiologic impact of AP change by comparing two time periods before and after change of AP guidelines in a tertiary care center as referral center for a total population of more than 4,500,000 inhabitants.

RESULTS:

After change of AP guidelines, twenty-five patients were diagnosed for IE at a median age of 6.9 years (range 0.1-19.4, female 48%). Modified Duke criteria were fulfilled for definite (12/25; 48%), or probable IE (13/25; 52%). The frequency of IE (cases per 1000 hospitalized patients) increased from 0.37% (1995-2005) to 0.59% (2006-2017) [p = 0.152], the annual incidence of IE (cases per 1000 CHD patients, < 20 years of age) increased from 0.195 ‰ to 0.399 ‰ [p = 0.072]. Postoperative IE (13/25; 52%), was associated mostly with prosthetic pulmonary valves (12/13; 92%). Pathogens were staphylococci spp. (8/25; 32%), streptococci spp. (7/25; 28%), HACEK (3/25; 12%), other (4/25; 16%), or culture-negative (3/25; 12%). Treatment included antibiotics (25/25; 100%), and cardiac surgery (16/25; 64%). The clinical findings and complications of pediatric IE including mortality (2/25; 8%) did not differ between the two time periods.

CONCLUSIONS:

Pediatric IE remains a severe cardiac disease with a comparable clinical picture. Unless increasing absolute case numbers of IE, the relative case number of IE remains stable despite AP change. The high number of prosthetic pulmonary valve associated IE needs further evaluation and therapeutic alternatives.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Guias como Assunto / Antibioticoprofilaxia / Endocardite / Antibacterianos Tipo de estudo: Guideline / Incidence_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn País como assunto: Europa Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Guias como Assunto / Antibioticoprofilaxia / Endocardite / Antibacterianos Tipo de estudo: Guideline / Incidence_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Limite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn País como assunto: Europa Idioma: En Ano de publicação: 2020 Tipo de documento: Article