Encephalopathy following ingestion of Lead-contaminated opium; magnetic resonance imaging findings.
BMC Neurol
; 20(1): 166, 2020 May 01.
Article
em En
| MEDLINE
| ID: mdl-32357843
ABSTRACT
BACKGROUND:
Encephalopathy is an uncommon but serious presentation of lead toxicity.OBJECTIVE:
We aimed to determine and follow-up the brain magnetic resonance imaging (MRI) abnormalities in the patients with lead encephalopathy due to ingestion of lead contaminated opium.METHODS:
In a cross-sectional study during lead-contaminated opium outbreak, all lead-poisoned patients with any signs/symptoms of encephalopathy were included.RESULTS:
Of 19 patients with lead encephalopathy, five died early and other five could not be sent to MRI during their hospitalization period. Mean age was 51 ± 11 years and males were dominant (89%). Median [IQR] blood lead level (BLL) was 101 [81, 108] µg/dL (range; 50 to 200 µg/dL). There was no correlation between MRI findings and signs/symptoms. MRI was normal in six and abnormal in three. Bilateral symmetric involvement of parieto-occipital lobes was observed. Gray matter, gray-white matter junction, and subcortical white matter were also affected. Follow-up MRI was performed in two with abnormal MRI which showed complete and near complete resolution of the abnormalities after cessation of opium use and treatment.CONCLUSION:
There was no correlation between MRI findings and BLL. Complete recovery of brain MRI lesions was detected after cessation of opium use.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ópio
/
Encefalopatias
/
Imageamento por Ressonância Magnética
/
Dependência de Ópio
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Intoxicação por Chumbo
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article