Exploring tryptamine conjugates as pronucleotides of phosphate-modified 7-methylguanine nucleotides targeting cap-dependent translation.

Golojuch, Sebastian; Kopcial, Michal; Strzelecka, Dominika; Kasprzyk, Renata; Baran, Natalia; Sikorski, Pawel J; Kowalska, Joanna; Jemielity, Jacek

Golojuch, Sebastian; Kopcial, Michal; Strzelecka, Dominika; Kasprzyk, Renata; Baran, Natalia; Sikorski, Pawel J; Kowalska, Joanna; Jemielity, Jacek.

Afiliação

Golojuch S; Centre of New Technologies, University of Warsaw, S. Banacha 2c, 02-097 Warsaw, Poland; Faculty of Chemistry, University of Warsaw, L. Pasteura 1, 02-093 Warsaw, Poland.
Kopcial M; Centre of New Technologies, University of Warsaw, S. Banacha 2c, 02-097 Warsaw, Poland; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, L. Pasteura 5, 02-093 Warsaw, Poland; College of Inter-Faculty Individual Studies in Mathematics and Natural Sc
Strzelecka D; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, L. Pasteura 5, 02-093 Warsaw, Poland.
Kasprzyk R; Centre of New Technologies, University of Warsaw, S. Banacha 2c, 02-097 Warsaw, Poland; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, L. Pasteura 5, 02-093 Warsaw, Poland; College of Inter-Faculty Individual Studies in Mathematics and Natural Sc
Baran N; Centre of New Technologies, University of Warsaw, S. Banacha 2c, 02-097 Warsaw, Poland; Faculty of Biology, University of Warsaw, I. Miecznikowa 1, 02-096 Warsaw, Poland.
Sikorski PJ; Centre of New Technologies, University of Warsaw, S. Banacha 2c, 02-097 Warsaw, Poland.
Kowalska J; Division of Biophysics, Institute of Experimental Physics, Faculty of Physics, University of Warsaw, L. Pasteura 5, 02-093 Warsaw, Poland. Electronic address: jkowalska@fuw.edu.pl.
Jemielity J; Centre of New Technologies, University of Warsaw, S. Banacha 2c, 02-097 Warsaw, Poland. Electronic address: j.jemielity@cent.uw.edu.pl.

Bioorg Med Chem ; 28(13): 115523, 2020 07 01.

Article em En | MEDLINE | ID: mdl-32362385

Assuntos

Fator de Iniciação 4E em Eucariotos/genética; Guanina/análogos & derivados; Nucleotídeos/química; Fosfatos/química; Triptaminas/química; Endorribonucleases/metabolismo; Variação Genética; Guanina/química; Guanosina/análogos & derivados; Guanosina/química; Humanos; Modelos Moleculares; Proteínas do Tecido Nervoso/metabolismo; Motivos de Nucleotídeos; Nucleotídeos/genética; Biossíntese de Proteínas; Análogos de Capuz de RNA/química; Análogos de Capuz de RNA/genética; RNA Mensageiro/química; RNA Mensageiro/genética

Palavras-chave

7-methylguanosine; DcpS; Pronucleotide; Translation inhibition; Tryptamine; eIF4E; mRNA cap

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fosfatos / Triptaminas / Fator de Iniciação 4E em Eucariotos / Guanina / Nucleotídeos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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