Zinc Oxide Nanoparticles Induce Mitochondrial Biogenesis Impairment and Cardiac Dysfunction in Human iPSC-Derived Cardiomyocytes.

Li, Yujie; Li, Fengxiang; Zhang, Lincong; Zhang, Chi; Peng, Hui; Lan, Feng; Peng, Shuangqing; Liu, Chao; Guo, Jiabin

Li, Yujie; Li, Fengxiang; Zhang, Lincong; Zhang, Chi; Peng, Hui; Lan, Feng; Peng, Shuangqing; Liu, Chao; Guo, Jiabin.

Afiliação

Li Y; Graduate School, Academy of Military Medical Sciences, Beijing, People's Republic of China.
Li F; Department of Operational Medical Protection, PLA Center for Disease Control and Prevention, Beijing, People's Republic of China.
Zhang L; Department of Operational Medical Protection, PLA Center for Disease Control and Prevention, Beijing, People's Republic of China.
Zhang C; Department of Operational Medical Protection, PLA Center for Disease Control and Prevention, Beijing, People's Republic of China.
Peng H; Department of Operational Medical Protection, PLA Center for Disease Control and Prevention, Beijing, People's Republic of China.
Lan F; Department of Operational Medical Protection, PLA Center for Disease Control and Prevention, Beijing, People's Republic of China.
Peng S; Beijing Key Laboratory for Cardiovascular Precision Medicines, Anzhen Hospital, Capital Medical University, Beijing, People's Republic of China.
Liu C; Department of Operational Medical Protection, PLA Center for Disease Control and Prevention, Beijing, People's Republic of China.
Guo J; Graduate School, Academy of Military Medical Sciences, Beijing, People's Republic of China.

Int J Nanomedicine ; 15: 2669-2683, 2020.

Article em En | MEDLINE | ID: mdl-32368048

Assuntos

Coração/fisiopatologia; Células-Tronco Pluripotentes Induzidas/citologia; Miócitos Cardíacos/metabolismo; Nanopartículas/toxicidade; Biogênese de Organelas; Óxido de Zinco/toxicidade; Diferenciação Celular/efeitos dos fármacos; DNA Mitocondrial/genética; Coração/efeitos dos fármacos; Humanos; Células-Tronco Pluripotentes Induzidas/efeitos dos fármacos; Masculino; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Mitocôndrias/efeitos dos fármacos; Mitocôndrias/metabolismo; Miócitos Cardíacos/efeitos dos fármacos; Nanopartículas/ultraestrutura; Coativador 1-alfa do Receptor gama Ativado por Proliferador de Peroxissomo/metabolismo

Palavras-chave

PGC-1α; Zinc oxide nanoparticles; ZnO NPs; cardiac dysfunction; hiPSC-CMs; human induced pluripotent stem cells-derived cardiomyocytes; mitochondrial biogenesis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Óxido de Zinco / Biogênese de Organelas / Miócitos Cardíacos / Nanopartículas / Células-Tronco Pluripotentes Induzidas / Coração Tipo de estudo: Prognostic_studies Limite: Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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