Hypermethylation-mediated down-regulation of lncRNA TBX5-AS1:2 in Tetralogy of Fallot inhibits cell proliferation by reducing TBX5 expression.

Ma, Jing; Chen, Shiyu; Hao, Lili; Sheng, Wei; Chen, WeiCheng; Ma, Xiaojing; Zhang, Bowen; Ma, Duan; Huang, Guoying

Ma, Jing; Chen, Shiyu; Hao, Lili; Sheng, Wei; Chen, WeiCheng; Ma, Xiaojing; Zhang, Bowen; Ma, Duan; Huang, Guoying.

Afiliação

Ma J; Department of Facial Plastic and Reconstructive Surgery, ENT Institute, Eye & ENT Hospital, Fudan University, Shanghai, China.
Chen S; Department of Biochemistry and Molecular Biology, Research Center for Birth Defects, Institutes of Biomedical Sciences, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Hao L; Department of Biochemistry and Molecular Biology, Research Center for Birth Defects, Institutes of Biomedical Sciences, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Sheng W; Department of Biochemistry and Molecular Biology, Research Center for Birth Defects, Institutes of Biomedical Sciences, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Chen W; Children's Hospital of Fudan University, Shanghai, China.
Ma X; Children's Hospital of Fudan University, Shanghai, China.
Zhang B; Children's Hospital of Fudan University, Shanghai, China.
Ma D; Department of Biochemistry and Molecular Biology, Research Center for Birth Defects, Institutes of Biomedical Sciences, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Fudan University, Shanghai, China.
Huang G; Department of Biochemistry and Molecular Biology, Research Center for Birth Defects, Institutes of Biomedical Sciences, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, Fudan University, Shanghai, China.

J Cell Mol Med ; 24(11): 6472-6484, 2020 06.

Article em En | MEDLINE | ID: mdl-32368852

Assuntos

Proliferação de Células/genética; Metilação de DNA/genética; Regulação para Baixo/genética; RNA Longo não Codificante/genética; Proteínas com Domínio T/genética; Tetralogia de Fallot/genética; Linhagem Celular; Células HEK293; Humanos; Regiões Promotoras Genéticas/genética; RNA Mensageiro/genética

Palavras-chave

TBX5; RNA-RNA interaction; TOF; cell proliferation; lncRNA TBX5-AS1:2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tetralogia de Fallot / Regulação para Baixo / Metilação de DNA / Proteínas com Domínio T / Proliferação de Células / RNA Longo não Codificante Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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