Efficient Targeted Degradation via Reversible and Irreversible Covalent PROTACs.

Gabizon, Ronen; Shraga, Amit; Gehrtz, Paul; Livnah, Ella; Shorer, Yamit; Gurwicz, Neta; Avram, Liat; Unger, Tamar; Aharoni, Hila; Albeck, Shira; Brandis, Alexander; Shulman, Ziv; Katz, Ben-Zion; Herishanu, Yair; London, Nir

Gabizon, Ronen; Shraga, Amit; Gehrtz, Paul; Livnah, Ella; Shorer, Yamit; Gurwicz, Neta; Avram, Liat; Unger, Tamar; Aharoni, Hila; Albeck, Shira; Brandis, Alexander; Shulman, Ziv; Katz, Ben-Zion; Herishanu, Yair; London, Nir.

Afiliação

Gabizon R; Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 7610001, Israel.
Shraga A; Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 7610001, Israel.
Gehrtz P; Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 7610001, Israel.
Livnah E; Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 7610001, Israel.
Shorer Y; Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv 6997801, Israel.
Gurwicz N; Department of Immunology, The Weizmann Institute of Science, Rehovot 7610001, Israel.
Avram L; Department of Chemical Research Support, The Weizmann Institute of Science, Rehovot 7610001, Israel.
Unger T; Structural Proteomics Unit, Department of Life Sciences Core Facilities, The Weizmann Institute of Science, Rehovot 7610001, Israel.
Aharoni H; Structural Proteomics Unit, Department of Life Sciences Core Facilities, The Weizmann Institute of Science, Rehovot 7610001, Israel.
Albeck S; Structural Proteomics Unit, Department of Life Sciences Core Facilities, The Weizmann Institute of Science, Rehovot 7610001, Israel.
Brandis A; Life Sciences Core Facilities, Weizmann Institute of Science, Rehovot 7610001, Israel.
Shulman Z; Department of Immunology, The Weizmann Institute of Science, Rehovot 7610001, Israel.
Katz BZ; Department of Hematology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, and Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv 6997801, Israel.
Herishanu Y; Department of Hematology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, and Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv 6997801, Israel.
London N; Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 7610001, Israel.

J Am Chem Soc ; 142(27): 11734-11742, 2020 07 08.

Article em En | MEDLINE | ID: mdl-32369353

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article