The yeast Hrq1 helicase stimulates Pso2 translesion nuclease activity and thereby promotes DNA interstrand crosslink repair.

Rogers, Cody M; Lee, Chun-Ying; Parkins, Samuel; Buehler, Nicholas J; Wenzel, Sabine; Martínez-Márquez, Francisco; Takagi, Yuichiro; Myong, Sua; Bochman, Matthew L

Rogers, Cody M; Lee, Chun-Ying; Parkins, Samuel; Buehler, Nicholas J; Wenzel, Sabine; Martínez-Márquez, Francisco; Takagi, Yuichiro; Myong, Sua; Bochman, Matthew L.

Afiliação

Rogers CM; Molecular and Cellular Biochemistry Department, Indiana University, Bloomington, Indiana, USA.
Lee CY; Department of Biophysics, Johns Hopkins University, Baltimore, Maryland, USA.
Parkins S; Department of Biology, Johns Hopkins University, Baltimore, Maryland, USA.
Buehler NJ; Molecular and Cellular Biochemistry Department, Indiana University, Bloomington, Indiana, USA.
Wenzel S; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Martínez-Márquez F; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Takagi Y; Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Myong S; Department of Biophysics, Johns Hopkins University, Baltimore, Maryland, USA.
Bochman ML; Molecular and Cellular Biochemistry Department, Indiana University, Bloomington, Indiana, USA. Electronic address: bochman@indiana.edu.

J Biol Chem ; 295(27): 8945-8957, 2020 07 03.

Article em En | MEDLINE | ID: mdl-32371399

Assuntos

Reparo do DNA/fisiologia; Endodesoxirribonucleases/metabolismo; RecQ Helicases/metabolismo; Proteínas de Saccharomyces cerevisiae/metabolismo; DNA/metabolismo; Dano ao DNA/fisiologia; Proteínas de Ligação a DNA/metabolismo; RecQ Helicases/fisiologia; Saccharomyces cerevisiae/metabolismo; Proteínas de Saccharomyces cerevisiae/fisiologia

Palavras-chave

DNA damage; DNA helicase; DNA interstrand crosslink (ICL) repair; DNA repair; DNA-protein interaction; Hrq1; Pso2; RECQL4; SNM1A; Saccharomyces cerevisiae; helicase; nuclease; single-molecule Förster resonance energy transfer (smFRET)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Saccharomyces cerevisiae / Reparo do DNA / Endodesoxirribonucleases / RecQ Helicases Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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