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High-Throughput Generation of Bipod (Fab × scFv) Bispecific Antibodies Exploits Differential Chain Expression and Affinity Capture.
Nesspor, Thomas C; Kinealy, Kyle; Mazzanti, Nicholas; Diem, Michael D; Boye, Kevin; Hoffman, Hunter; Springer, Christine; Sprenkle, Justin; Powers, Gordon; Jiang, Haiyan; La Porte, Sherry L; Ganesan, Rajkumar; Singh, Sanjaya; Zwolak, Adam.
Afiliação
  • Nesspor TC; Biologics Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA.
  • Kinealy K; Biologics Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA.
  • Mazzanti N; Biologics Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA.
  • Diem MD; Biologics Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA.
  • Boye K; Biologics Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA.
  • Hoffman H; Biologics Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA.
  • Springer C; Biologics Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA.
  • Sprenkle J; Biologics Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA.
  • Powers G; Biologics Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA.
  • Jiang H; Biologics Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA.
  • La Porte SL; Biologics Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA.
  • Ganesan R; Biologics Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA.
  • Singh S; Biologics Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA.
  • Zwolak A; Biologics Discovery, Janssen Research & Development, LLC, Spring House, PA, 19477, USA. azwolak1@its.jnj.com.
Sci Rep ; 10(1): 7557, 2020 05 05.
Article em En | MEDLINE | ID: mdl-32372058
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos Fab das Imunoglobulinas / Engenharia de Proteínas / Anticorpos Biespecíficos / Anticorpos de Cadeia Única Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos Fab das Imunoglobulinas / Engenharia de Proteínas / Anticorpos Biespecíficos / Anticorpos de Cadeia Única Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article