IGF1R constitutive activation expands luminal progenitors and influences lineage differentiation during breast tumorigenesis.

Farabaugh, Susan M; Litzenburger, Beate C; Elangovan, Ashuvinee; Pecar, Geoffrey; Walheim, Lauren; Atkinson, Jennifer M; Lee, Adrian V

Farabaugh, Susan M; Litzenburger, Beate C; Elangovan, Ashuvinee; Pecar, Geoffrey; Walheim, Lauren; Atkinson, Jennifer M; Lee, Adrian V.

Afiliação

Farabaugh SM; Women's Cancer Research Center, Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, Magee Women's Research Institute, USA.
Litzenburger BC; Lester and Sue Smith Breast Center, Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, 77030, USA.
Elangovan A; Women's Cancer Research Center, Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, Magee Women's Research Institute, USA.
Pecar G; Women's Cancer Research Center, Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, Magee Women's Research Institute, USA.
Walheim L; Women's Cancer Research Center, Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, Magee Women's Research Institute, USA.
Atkinson JM; Women's Cancer Research Center, Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, Magee Women's Research Institute, USA.
Lee AV; Women's Cancer Research Center, Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, Magee Women's Research Institute, USA. Electronic address: leeav@upmc.edu.

Dev Biol ; 463(1): 77-87, 2020 07 01.

Article em En | MEDLINE | ID: mdl-32376245

Assuntos

Neoplasias da Mama/metabolismo; Diferenciação Celular/fisiologia; Receptor IGF Tipo 1/metabolismo; Animais; Mama/citologia; Mama/metabolismo; Linhagem Celular Tumoral; Linhagem da Célula/fisiologia; Transformação Celular Neoplásica/metabolismo; Células Epiteliais/citologia; Feminino; Humanos; Fator de Crescimento Insulin-Like I/metabolismo; Glândulas Mamárias Animais/citologia; Glândulas Mamárias Animais/metabolismo; Camundongos; Camundongos Endogâmicos BALB C; Camundongos Transgênicos; Células NIH 3T3; Receptor IGF Tipo 1/fisiologia; Transdução de Sinais; Células-Tronco/citologia

Palavras-chave

Breast cancer; Differentiation; IGF1R; Lineages

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Diferenciação Celular / Receptor IGF Tipo 1 Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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