Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur.
Nat Struct Mol Biol
; 27(6): 529-532, 2020 06.
Article
em En
| MEDLINE
| ID: mdl-32382072
ABSTRACT
The antineoplastic drug carmofur is shown to inhibit the SARS-CoV-2 main protease (Mpro). Here, the X-ray crystal structure of Mpro in complex with carmofur reveals that the carbonyl reactive group of carmofur is covalently bound to catalytic Cys145, whereas its fatty acid tail occupies the hydrophobic S2 subsite. Carmofur inhibits viral replication in cells (EC50 = 24.30 µM) and is a promising lead compound to develop new antiviral treatment for COVID-19.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cisteína Endopeptidases
/
Proteínas não Estruturais Virais
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Fluoruracila
/
Betacoronavirus
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article