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Acute zoster plasma contains elevated amyloid, correlating with Aß42 and amylin levels, and is amyloidogenic.
Bubak, Andrew N; Beseler, Cheryl; Como, Christina N; Tyring, Stephen K; Haley, Christopher; Mescher, Teresa; Hassell, James E; Cohrs, Randall J; Potter, Huntington; Nagel, Maria A.
Afiliação
  • Bubak AN; Department of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Mail Stop B182, Aurora, CO, 80045, USA.
  • Beseler C; Department of Psychology, Colorado State University, Fort Collins, CO, 80523, USA.
  • Como CN; Department of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Mail Stop B182, Aurora, CO, 80045, USA.
  • Tyring SK; Department of Dermatology, Center for Clinical Studies, University of Texas Health Science Center, Houston, TX, 77598, USA.
  • Haley C; Department of Dermatology, Center for Clinical Studies, University of Texas Health Science Center, Houston, TX, 77598, USA.
  • Mescher T; Department of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Mail Stop B182, Aurora, CO, 80045, USA.
  • Hassell JE; Department of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Mail Stop B182, Aurora, CO, 80045, USA.
  • Cohrs RJ; Department of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Mail Stop B182, Aurora, CO, 80045, USA.
  • Potter H; Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO, 80045, USA.
  • Nagel MA; Department of Neurology, University of Colorado School of Medicine, 12700 E. 19th Avenue, Mail Stop B182, Aurora, CO, 80045, USA.
J Neurovirol ; 26(3): 422-428, 2020 06.
Article em En | MEDLINE | ID: mdl-32385803
Herpes zoster is associated with an increased dementia and neovascular macular degeneration risk and a decline in glycemic control in diabetes mellitus. Because amyloid is present and pathogenic in these diseases, we quantified amyloid, Aß40, Aß42, and amylin in 14 zoster and 10 control plasmas. Compared with controls, zoster plasma had significantly elevated amyloid that correlated with Aß42 and amylin levels and increased amyloid aggregation with addition of exogenous Aß42 or amylin. These results suggest that zoster plasma contains factor(s) that promotes aggregation of amyloidogenic peptides, potentially contributing to the toxic amyloid burden and explaining accelerated disease progression following zoster.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Peptídeos beta-Amiloides / Herpesvirus Humano 3 / Polipeptídeo Amiloide das Ilhotas Pancreáticas / Agregação Patológica de Proteínas / Herpes Zoster Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Peptídeos beta-Amiloides / Herpesvirus Humano 3 / Polipeptídeo Amiloide das Ilhotas Pancreáticas / Agregação Patológica de Proteínas / Herpes Zoster Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article