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Kusnezosines A-C, three C19-diterpenoid alkaloids with a new skeleton from Aconitum kusnezoffii Reichb. var. gibbiferum.
Li, Yu-Zhu; Qin, Li-Li; Gao, Feng; Shan, Lian-Hai; Zhou, Xian-Li.
Afiliação
  • Li YZ; Laboratory of Chemistry and Biodiversity, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, PR China; Key laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, Sichuan, PR China.
  • Qin LL; Laboratory of Chemistry and Biodiversity, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, PR China.
  • Gao F; Laboratory of Chemistry and Biodiversity, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, PR China.
  • Shan LH; Laboratory of Chemistry and Biodiversity, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, PR China.
  • Zhou XL; Laboratory of Chemistry and Biodiversity, School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, PR China; Key laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, Sichuan, PR China. Electroni
Fitoterapia ; 144: 104609, 2020 Jul.
Article em En | MEDLINE | ID: mdl-32387374
ABSTRACT
Kusnezosines A-C (1-3), three C19-diterpenoid alkaloids with a new skeleton which featured an undescribed lactone type D-ring, were isolated from the roots of Aconitum kusnezoffii Reichb. var. gibbiferum. Kusnezosines A-C are the first naturally occurred C19-diterpenoid alkaloids which possessing an unprecedented lactone D ring, this structure was formed by the cleavage of bond between C-15 and C-16 and a successive lactonization. Their structures were established on the basis of comprehensive spectroscopic data analysis. Besides, another 12 known ones were isolated from this plant, analgesic activity tests on the isolated alkaloids were also carried out.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Raízes de Plantas / Aconitum / Diterpenos / Alcaloides / Analgésicos Limite: Animals País como assunto: Asia Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Raízes de Plantas / Aconitum / Diterpenos / Alcaloides / Analgésicos Limite: Animals País como assunto: Asia Idioma: En Ano de publicação: 2020 Tipo de documento: Article