Mapping the breakome reveals tight regulation on oncogenic super-enhancers.
Mol Cell Oncol
; 7(3): 1698933, 2020.
Article
em En
| MEDLINE
| ID: mdl-32391416
ABSTRACT
DNA double-strand breaks (DSBs) could be deleterious and lead to age-related diseases, such as cancer. Recent evidence, however, associates DSBs with vital cellular processes. As discussed here, genome-wide mapping of DSBs revealed an unforeseen coupling mechanism between transcription and DNA repair at super-enhancers, as means of hypertranscription of oncogenic drivers.
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MEDLINE
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En
Ano de publicação:
2020
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Article