Trifluoromethoxypyrazines: Preparation and Properties.
Molecules
; 25(9)2020 May 09.
Article
em En
| MEDLINE
| ID: mdl-32397388
ABSTRACT
The incorporation of the trifluoromethoxy group into organic molecules has become very popular due to the unique properties of the named substituent that has a "pseudohalogen" character, while the chemical properties of the synthesized compound, especially heterocycles with such a group, are less studied. As trifluoromethoxy-substituted pyrazines are still unknown, we have developed efficient and scalable methods for 2-chloro-5-trifluoromethoxypyrazine synthesis, showing the synthetic utility of this molecule for Buchwald-Hartwig amination and the Kumada-Corriu and Suzuki and Sonogashira coupling reactions. Some comparisons of chlorine atom and trifluoromethoxy group stability in these transformations have been carried out.
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MEDLINE
Assunto principal:
Pirazinas
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article