Blood group P1 antigen-bearing glycoproteins are functional but less efficient receptors of Shiga toxin than conventional glycolipid-based receptors.

Morimoto, Kanta; Suzuki, Noriko; Tanida, Isei; Kakuta, Soichiro; Furuta, Yoko; Uchiyama, Yasuo; Hanada, Kentaro; Suzuki, Yusuke; Yamaji, Toshiyuki

Morimoto, Kanta; Suzuki, Noriko; Tanida, Isei; Kakuta, Soichiro; Furuta, Yoko; Uchiyama, Yasuo; Hanada, Kentaro; Suzuki, Yusuke; Yamaji, Toshiyuki.

Afiliação

Morimoto K; Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Tokyo, Japan.
Suzuki N; Department of Materials and Applied Chemistry, College of Science and Technology, Nihon University, Tokyo, Japan.
Tanida I; Graduate School of Science and Technology, Niigata University, Niigata, Japan nrsuzuki@gs.niigata-u.ac.jp tyamaji@nih.go.jp.
Kakuta S; Department of Cellular and Molecular Neuropathology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Furuta Y; Department of Cellular and Molecular Neuropathology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Uchiyama Y; Laboratory of Morphology and Image Analysis, Biomedical Research Center, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Hanada K; Department of Cellular and Molecular Neuropathology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Suzuki Y; Department of Cellular and Molecular Neuropathology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Yamaji T; Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, Tokyo, Japan.

J Biol Chem ; 295(28): 9490-9501, 2020 07 10.

Article em En | MEDLINE | ID: mdl-32409578

Assuntos

Globosídeos/metabolismo; Glicolipídeos/metabolismo; Receptores de Superfície Celular/metabolismo; Toxina Shiga/metabolismo; Animais; Galactosiltransferases/genética; Galactosiltransferases/metabolismo; Globosídeos/genética; Glicolipídeos/genética; Células HeLa; Humanos; Camundongos; Receptores de Superfície Celular/genética; Toxina Shiga/genética

Palavras-chave

CRISPR/Cas; Shiga toxin; blood group P1 antigen; globotriaosylceramide (Gb3); glycan remodeling; glycolipid; glycomics; glycoprotein; receptor; retrograde transport

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicolipídeos / Receptores de Superfície Celular / Toxina Shiga / Globosídeos Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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