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Topical Anti-Inflammatory Activity of Essential Oils of Alpinia calcarata Rosc., Its Main Constituents, and Possible Mechanism of Action.
Chandrakanthan, Madhuvanthi; Handunnetti, Shiroma M; Premakumara, Galbada Sirimal Arachchige; Kathirgamanathar, Selvaluxmy.
Afiliação
  • Chandrakanthan M; Industrial Technology Institute, Colombo-07, Sri Lanka.
  • Handunnetti SM; Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo-03, Sri Lanka.
  • Premakumara GSA; Institute of Biochemistry, Molecular Biology and Biotechnology, University of Colombo, Colombo-03, Sri Lanka.
  • Kathirgamanathar S; Faculty of Nursing, University of Colombo, Sri Jayewardenepura, Thalapathpitiya, Nugegoda, Sri Lanka.
Article em En | MEDLINE | ID: mdl-32419793
This study aimed at investigating the anti-inflammatory potential of essential oil from rhizome and leaf of Alpinia calcarata Rosc. (ACEO) with the focus of its topical anti-inflammatory activity along with its dominant compounds 1,8-cineole and α-terpineol using mouse ear edema model. ACEOs were analyzed by GC-MS. The anti-inflammatory activity was determined by studying the inhibition of overproduction of proinflammatory mediators-nitric oxide, reactive oxygen species, prostaglandins, cyclooxygenases, and cytokines induced by lipopolysaccharides in murine macrophages. Topical anti-inflammatory and antinociceptive activity was studied by 12-O-tetradecanoylphorbol-13-acetate (TPA) induced skin inflammation and formalin-induced pain model in mice, respectively. Rhizome oil has 1,8-cineole (31.08%), α-terpineol (10.31%), and fenchyl acetate (10.73%) as major compounds whereas the ACEO from leaves has 1,8-cineole (38.45%), a-terpineol (11.62%), and camphor (10%). ACEOs reduced the production of inflammatory mediators in vitro in a concentration-dependent manner. Further, ACEO and its major compounds reduced ear thickness, weight, myeloperoxidase, and cytokines significantly (p < 0.01) in mouse ear. Dose-dependent reduction in flinching and licking in both the phases of pain sensation concludes the topical analgesic effect. Our findings suggest the potency of topical use of ACEOs for inflammatory disease conditions.

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2020 Tipo de documento: Article