Shared proteomic effects of cerebral atherosclerosis and Alzheimer's disease on the human brain.
Nat Neurosci
; 23(6): 696-700, 2020 06.
Article
em En
| MEDLINE
| ID: mdl-32424284
ABSTRACT
Cerebral atherosclerosis contributes to dementia via unclear processes. We performed proteomic sequencing of dorsolateral prefrontal cortex in 438 older individuals and found associations between cerebral atherosclerosis and reduced synaptic signaling and between RNA splicing and increased oligodendrocyte development and myelination. Consistently, single-cell RNA sequencing showed cerebral atherosclerosis associated with higher oligodendrocyte abundance. A subset of proteins and modules associated with cerebral atherosclerosis was also associated with Alzheimer's disease, suggesting shared mechanisms.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Envelhecimento
/
Arteriosclerose Intracraniana
/
Córtex Pré-Frontal
/
Proteômica
/
Doença de Alzheimer
/
Proteínas do Tecido Nervoso
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article