Phylogenetic tree building in the genomic age.
Nat Rev Genet
; 21(7): 428-444, 2020 07.
Article
em En
| MEDLINE
| ID: mdl-32424311
ABSTRACT
Knowing phylogenetic relationships among species is fundamental for many studies in biology. An accurate phylogenetic tree underpins our understanding of the major transitions in evolution, such as the emergence of new body plans or metabolism, and is key to inferring the origin of new genes, detecting molecular adaptation, understanding morphological character evolution and reconstructing demographic changes in recently diverged species. Although data are ever more plentiful and powerful analysis methods are available, there remain many challenges to reliable tree building. Here, we discuss the major steps of phylogenetic analysis, including identification of orthologous genes or proteins, multiple sequence alignment, and choice of substitution models and inference methodologies. Understanding the different sources of errors and the strategies to mitigate them is essential for assembling an accurate tree of life.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Filogenia
/
Genoma
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Genômica
/
Modelos Genéticos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article