Bone metastasis is associated with poor prognosis in metastatic papillary renal cell carcinoma patients treated with first agent angiogenesis inhibitors.
Urol Oncol
; 38(8): 686.e1-686.e9, 2020 08.
Article
em En
| MEDLINE
| ID: mdl-32430250
ABSTRACT
OBJECTIVE:
Papillary renal cell carcinoma (papRCC) is a rare (10%-15%) subtype of renal cancer. Few prognostic biomarkers have been described in metastatic papRCC (m-papRCC) patients treated with vascular endothelial growth factor receptor tyrosine kinase inhibitors (VEGFR-TKIs). We aimed to study the prognostic impact of bone metastases (BM) on response rate, progression-free and overall survival (PFS and OS) in patients with m-papRCC treated with first agent VEGFR-TKIs. PATIENTS ANDMETHODS:
A multicentric, retrospective analysis of patient records was conducted. BM were detected by computed tomography and/or bone scintigraphy. The International Metastatic RCC Database Consortium (IMDC) score was calculated at start of first agent VEGFR-TKI treatment.RESULTS:
Forty-nine patients were included. Best objective response was partial response in 20%, stable disease in 60% and early progressive disease in 20% of patients. Median PFS (mPFS) was 6.0 months and median OS (mOS) 14.0 months after start of first agent VEGFR-TKI. The IMDC score correlated with mOS 77.5 months in good, 17.0 months in intermediate and 8.0 months in poor risk patients (Pâ¯=â¯0.002). Patients with BM had a poorer outcome compared to patients without BM mPFS was 4.0 vs. 7.0 months (Pâ¯=â¯0.006) and mOS 7.5 vs. 19.0 months (Pâ¯=â¯0.002). On bivariate analysis, the presence of BM was independently associated with PFS (Pâ¯=â¯0.02) and OS (Pâ¯=â¯0.049), independent of the IMDC risk groups.CONCLUSION:
In m-papRCC patients treated with first agent VEGFR-TKIs, the presence of BM is an unfavorable prognostic factor, associated with shorter PFS and OS.Palavras-chave
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Base de dados:
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Assunto principal:
Pirimidinas
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Sulfonamidas
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Neoplasias Ósseas
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Carcinoma de Células Renais
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Inibidores da Angiogênese
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Sorafenibe
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Sunitinibe
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Axitinibe
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Neoplasias Renais
Limite:
Adult
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Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article