An anti-inflammatory isoflavone from soybean inoculated with a marine fungus Aspergillus terreus C23-3.
Biosci Biotechnol Biochem
; 84(8): 1546-1553, 2020 Aug.
Article
em En
| MEDLINE
| ID: mdl-32434451
ABSTRACT
A new isoflavone derivative compound 1 (psoralenone) was isolated from soybean inoculated with a marine fungus Aspergillus terreus C23-3, together with seven known compounds including isoflavones 2-6, butyrolactone I (7) and blumenol A (8). Their structures were elucidated by MS, NMR, and ECD. Psoralenone displayed moderate in vitro anti-inflammatory activity in the LPS-induced RAW264.7 cell model. Compound 2 (genistein) showed moderate acetylcholinesterase (AChE) inhibitory activity whereas compounds 2, 5 (biochanin A), 6 (psoralenol), and 7 exhibited potent larvicidal activity against brine shrimp. Compounds 3 (daidzein), 4 (4'-hydroxy-6,7-dimethoxyisoflavone), and 5-7 showed broad-spectrum anti-microbial activity, and compound 7 also showed moderate 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aspergillus
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Glycine max
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Lipopolissacarídeos
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Isoflavonas
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Anti-Inflamatórios
Limite:
Animals
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article