Plectrabarbene, a New Abietane Diterpene from Plectranthus barbatus Aerial Parts.
Molecules
; 25(10)2020 May 20.
Article
em En
| MEDLINE
| ID: mdl-32443693
ABSTRACT
A new abietane diterpene namely plectrabarbene (2), together with two known compounds sugiol (1) and 11,14-dihydroxy-8,11,13-abietatrien-7-one (3) have been isolated from the aerial parts of Plectranthus barbatus Andr. (Labiatae). The structures of these compounds were determined by various spectral techniques (e.g., UV, IR, NMR, and FAB) and by comparison with the literature data. A molecular docking study of the isolated diterpenes (1-3) was performed with AChE to gain an insight into their AChE inhibition mechanism. The results of docking experiments revealed that the all tested compounds showed binding affinity at the active site of AchE in comparison to donepezil.
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Base de dados:
MEDLINE
Assunto principal:
Inibidores da Colinesterase
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Plectranthus
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Componentes Aéreos da Planta
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Abietanos
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article