Spironolactone use does not increase the risk of female breast cancer recurrence: A retrospective analysis.
J Am Acad Dermatol
; 83(4): 1021-1027, 2020 10.
Article
em En
| MEDLINE
| ID: mdl-32446820
ABSTRACT
BACKGROUND:
Spironolactone is used off-label for androgenic alopecia because of its ability to arrest hair loss progression and long-term safety profile. However, little is known about the safety of spironolactone in breast cancer (BC) survivors. Because spironolactone has estrogenic effects, there is a theoretical risk for BC recurrence. Given that spironolactone is an important tool in the treatment of alopecia, we investigated whether spironolactone increased risk for BC recurrence.OBJECTIVE:
To determine whether spironolactone is associated with increased BC recurrence.METHODS:
A retrospective analysis was conducted using the Humana Insurance database. Patients with a history of BC were identified using International Classification of Diseases codes, stratified by spironolactone prescription, and also matched 11 using propensity score analysis. Patient characteristics and cancer recurrence rates between both cohorts were compared and analyzed.RESULTS:
BC recurrence developed in 123 patients (16.5%) who were prescribed spironolactone compared with 3649 patients (12.8%) who developed BC recurrence without spironolactone prescribed (P = .004). After propensity matching, adjusted Cox regression analysis showed no association between spironolactone and increased BC recurrence (adjusted hazard ratio, 0.966; 95% confidence interval, 0.807-1.156; P = .953).LIMITATIONS:
Retrospective study.CONCLUSION:
Spironolactone was not independently associated with increased BC recurrence and may be considered for the treatment of alopecia in BC survivors.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Espironolactona
/
Neoplasias da Mama
/
Antagonistas de Receptores de Mineralocorticoides
/
Uso Off-Label
/
Recidiva Local de Neoplasia
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Middle aged
País como assunto:
America do norte
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article