Association of Helicobacter pylori babA2 gene and gastric cancer risk: a meta-analysis.
BMC Cancer
; 20(1): 465, 2020 May 24.
Article
em En
| MEDLINE
| ID: mdl-32448131
ABSTRACT
BACKGROUND:
The association of Helicobacter pylori (H. pylori) babA2 gene with gastric cancer (GC) was reported by several studies, but results were inconsistent. This meta-analysis was performed to investigate the relationship between H. pylori babA2 gene and GC risk.METHODS:
Case-control studies involving the association between H. pylori babA2 gene and GC risk were systematically identified from PubMed databases. A meta-analysis was used to pool studies and to estimate odds ratios (ORs) with 95% confidence intervals (CIs) of H. pylori babA2 gene associated with GC risk.RESULTS:
Twenty studies were identified with a total of 1289 GC cases and 1081 controls. H. pylori babA2 gene was associated with an increased risk of GC by 2.05 fold (95% CI, 1.30-3.24, P = 0.002). In subgroup analysis, we found that H. pylori babA2 gene was significantly associated with GC risk in Asian population (OR = 2.63, 95% CI 1.36-5.09 P = 0.004) but not in South American population (OR = 1.35, 95% CI 0.69-2.64, P = 0.379).CONCLUSIONS:
This meta-analysis indicates that H. pylori babA2 gene may be associated with increased risk of GC, especially in Asian population.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
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Proteínas de Bactérias
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Infecções por Helicobacter
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Adesinas Bacterianas
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Polimorfismo de Nucleotídeo Único
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
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Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article