Oral Candida Mannan Concentrations Correlate with Symptoms/Signs of Ill Health and the Immune Status.
Mycopathologia
; 185(4): 629-637, 2020 Aug.
Article
em En
| MEDLINE
| ID: mdl-32462380
BACKGROUND: A relationship has been proposed between increases in oral Candida concentrations and host immunity. Therefore, the present study was conducted to investigate the relationship between oral Candida mannan concentrations and symptoms/signs of ill health and the immune status and also to examine whether health/the immune status may be evaluated based on oral Candida mannan concentrations. PATIENTS AND METHODS: The health conditions of 25 healthy individuals and 10 cancer patients receiving cytotoxic chemotherapy were assessed using a questionnaire and oral rinse solutions collected on consecutive days. Candida mannan concentrations in oral rinse solutions were measured using a commercial sandwich ELISA kit. RESULTS: The use of dentures was identified as a significant independent factor increasing Candida mannan concentrations. In a stratified analysis based on the use of dentures, significantly increased Candida mannan concentrations were detected in healthy volunteers with chills and in cancer patients with slight/moderate fever (37.5-38.4 °C) (multivariate analysis, p < 0.01) who were non-denture users. These symptoms/signs may be associated with (pre-)infection, during which the immune system is activated and needs to function well. CONCLUSIONS: The present results suggest that oral Candida mannan concentrations are a predictive marker for health/the immune status.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Candida
/
Saúde Bucal
/
Mananas
/
Boca
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article