Development of an UPSA Short Form for Use in Longitudinal Studies in the Early Alzheimer's Disease Spectrum.
J Prev Alzheimers Dis
; 7(3): 179-183, 2020.
Article
em En
| MEDLINE
| ID: mdl-32463071
ABSTRACT
BACKGROUND:
In individuals with only mild or very mild cognitive attenuations (i.e., so-called pre-clinical AD), performance-based measures of function may be superior to informant-based measures because of increased sensitivity, greater reliability, and fewer ceiling effects.OBJECTIVE:
We sought to determine if a performance-based measure of everyday function would demonstrate adequate psychometric properties and validity in the context of serial assessment over a one-year period in patients with Mild Cognitive Impairment (MCI) and early stage Alzheimer's disease (AD).DESIGN:
Participants were assessed with the performance-based measure at baseline, six weeks, and one year.SETTING:
A specialized center for the assessment and treatment of AD.PARTICIPANTS:
Three groups of subjects participated a healthy subjects (HS) older cognitively intact group (N=43), an MCI group (N=20), and an AD group (N=26). MEASUREMENTS A three subtest short form of the UCSD Performance-Based Skills Assessment (UPSA) (called the UPSA-3) was the measure of interest. It consisted of the Communication, Planning, and Finance subtests.RESULTS:
Mixed model repeated measures were used to assess performance over time. Large group effects were present (HS>MCI>AD). Additionally, the AD and MCI groups demonstrated declines over one year, while the HS group remained stable (group x time interaction p=.11). The MCI/AD group demonstrated adequate test-retest reliability and did not demonstrate ceiling or floor effects.CONCLUSION:
Our data indicate that the UPSA-3 is suitable for clinical trials in that it has adequate ecological coverage and reasonable psychometric properties, and perhaps most importantly, demonstrates validity in serial assessments.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Desempenho Psicomotor
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Doença de Alzheimer
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Disfunção Cognitiva
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Testes de Estado Mental e Demência
Tipo de estudo:
Observational_studies
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Prognostic_studies
Limite:
Aged
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Aged80
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article