MSC encapsulation in alginate microcapsules prolongs survival after intra-articular injection, a longitudinal in vivo cell and bead integrity tracking study.

Khatab, Sohrab; Leijs, Maarten J; van Buul, Gerben; Haeck, Joost; Kops, Nicole; Nieboer, Michael; Bos, P Koen; Verhaar, Jan A N; Bernsen, Monique; van Osch, Gerjo J V M

Khatab, Sohrab; Leijs, Maarten J; van Buul, Gerben; Haeck, Joost; Kops, Nicole; Nieboer, Michael; Bos, P Koen; Verhaar, Jan A N; Bernsen, Monique; van Osch, Gerjo J V M.

Afiliação

Khatab S; Department of Orthopaedics, Erasmus MC University Medical Center Rotterdam, Wytemaweg 80, 3015, CN, Rotterdam, the Netherlands.
Leijs MJ; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, Wytemaweg 80, 3015, CN, Rotterdam, the Netherlands.
van Buul G; Department of Orthopaedics, Erasmus MC University Medical Center Rotterdam, Wytemaweg 80, 3015, CN, Rotterdam, the Netherlands.
Haeck J; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, Wytemaweg 80, 3015, CN, Rotterdam, the Netherlands.
Kops N; Department of Orthopaedics, Erasmus MC University Medical Center Rotterdam, Wytemaweg 80, 3015, CN, Rotterdam, the Netherlands.
Nieboer M; Department of Radiology and Nuclear Medicine, Erasmus MC University Medical Center Rotterdam, Wytemaweg 80, 3015, CN, Rotterdam, the Netherlands.
Bos PK; Department of Orthopaedics, Erasmus MC University Medical Center Rotterdam, Wytemaweg 80, 3015, CN, Rotterdam, the Netherlands.
Verhaar JAN; Department of Orthopaedics, Erasmus MC University Medical Center Rotterdam, Wytemaweg 80, 3015, CN, Rotterdam, the Netherlands.
Bernsen M; Department of Orthopaedics, Erasmus MC University Medical Center Rotterdam, Wytemaweg 80, 3015, CN, Rotterdam, the Netherlands.
van Osch GJVM; Department of Orthopaedics, Erasmus MC University Medical Center Rotterdam, Wytemaweg 80, 3015, CN, Rotterdam, the Netherlands.

Cell Biol Toxicol ; 36(6): 553-570, 2020 12.

Article em En | MEDLINE | ID: mdl-32474743

Assuntos

Alginatos/química; Rastreamento de Células; Ácidos Hexurônicos/química; Articulações/cirurgia; Transplante de Células-Tronco Mesenquimais; Células-Tronco Mesenquimais/metabolismo; Osteoartrite/cirurgia; Adulto; Animais; Sobrevivência Celular; Células Cultivadas; Modelos Animais de Doenças; Feminino; Genes Reporter; Humanos; Injeções Intra-Articulares; Ácido Iodoacético; Articulações/metabolismo; Articulações/patologia; Luciferases de Vaga-Lume/genética; Luciferases de Vaga-Lume/metabolismo; Masculino; Células-Tronco Mesenquimais/imunologia; Pessoa de Meia-Idade; Osteoartrite/induzido quimicamente; Osteoartrite/metabolismo; Osteoartrite/patologia; Ratos Endogâmicos F344; Fatores de Tempo

Palavras-chave

Alginate; Cell encapsulation; Cell therapy; In vivo longitudinal imaging; Mesenchymal stem cells

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Osteoartrite / Transplante de Células-Tronco Mesenquimais / Alginatos / Rastreamento de Células / Células-Tronco Mesenquimais / Ácidos Hexurônicos / Articulações Tipo de estudo: Prognostic_studies Limite: Adult / Animals / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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