The 95% effective dose of nalbuphine in patient-controlled intravenous analgesia for patients undergoing laparoscopic total hysterectomy compared to equivalent sufentanil.
Medicine (Baltimore)
; 99(22): e20424, 2020 05 29.
Article
em En
| MEDLINE
| ID: mdl-32481441
ABSTRACT
PURPOSE:
To evaluate the 95% effective dose of nalbuphine in patient-controlled intravenous analgesia (PCIA) by the sequential method and compare the analgesia efficacy with the equivalent dose of sufentanil on patients undergoing laparoscopic total hysterectomy.METHODS:
In the first part, we defined a successful analgesia as the highest VAS ≤3 in 24âhours postoperatively. On the contrary, a failed analgesia was the highest VAS>3. According to the last patient's outcome, the next patients would be given an increase or decreased dose grade. This process ended up with 9 cross-over points. In the second part, 60 patients undergoing laparoscopic total hysterectomy were selected. They were randomly divided into 2 groups (nâ=â30 each group) receiving sufentanil 1.78âµg/kg (group S) and nalbuphine 1.78âmg/kg (groupâN). PCIA pump was given at the end of the operation with 5âmL bonus loading. The total amount of PCIA was 100âmL and programmed to deliver 0.5âmL each time with a lockout interval of 15âminutes and the background infusion amount of 2âmL/h. The VAS score and Ramsay score of were collected after the operation, the number of effective pressing times of PCIA were also recorded. Adverse reactions were documented in detail.RESULTS:
The 95% effective dose of nalbuphine in PCIA on patients undergoing laparoscopic total hysterectomy was 1.78âmg/kg. There was no significant difference in VAS between the sufentanil group and the nalbuphine groups (Pâ>â.05), but the number of the use of PCIA in the group S was more than that in the group N obviously (P <.05). The group S has a lower ramsay sedation score than group N at every time point. (P <.05). The incidence of nausea and vomiting was not statistically significant differences between two groups in the first 24âhours after colonoscopy (Pâ>â q .05).CONCLUSION:
Nalbuphine 1.78âmg/kg in PCIA is recommended for the patients undergoing laparoscopic total hysterectomy. And nalbuphine is a reasonable alternative to sufentanil when used in PCIA.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dor Pós-Operatória
/
Sufentanil
/
Laparoscopia
/
Analgésicos Opioides
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Histerectomia
/
Nalbufina
Tipo de estudo:
Clinical_trials
Limite:
Female
/
Humans
/
Middle aged
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article