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Plasma Proteomic Analysis Reveals Age-Specific Changes in Platelet- and Endothelial Cell-Derived Proteins and Regulators of Plasma Coagulation and Fibrinolysis.
McCafferty, Conor; Busuttil-Crellin, Xavier; Cai, Tengyi; Monagle, Paul; Goldenberg, Neil A; Ignjatovic, Vera.
Afiliação
  • McCafferty C; Haematology Research Laboratory, Murdoch Children's Research Institute, Melbourne, Australia.
  • Busuttil-Crellin X; Haematology Research Laboratory, Murdoch Children's Research Institute, Melbourne, Australia.
  • Cai T; Haematology Research Laboratory, Murdoch Children's Research Institute, Melbourne, Australia.
  • Monagle P; Haematology Research Laboratory, Murdoch Children's Research Institute, Melbourne, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Australia; Department of Clinical Haematology, Royal Children's Hospital, Melbourne, Australia.
  • Goldenberg NA; Divisions of Hematology, Departments of Pediatrics and Medicine, Johns Hopkins University School of Medicine, Baltimore, St. Petersburg, FL; Johns Hopkins All Children's Institute for Clinical and Translational Research, St Petersburg, FL.
  • Ignjatovic V; Haematology Research Laboratory, Murdoch Children's Research Institute, Melbourne, Australia; Department of Paediatrics, The University of Melbourne, Melbourne, Australia. Electronic address: vera.ignjatovic@mcri.edu.au.
J Pediatr ; 221S: S29-S36, 2020 06.
Article em En | MEDLINE | ID: mdl-32482231
ABSTRACT
This post hoc study of a plasma proteomic database investigated hemostatic proteins in the context of developmental hemostasis. Twenty-seven hemostatic proteins changed expression with age, and the hemostatic profile of neonates was unique. Appreciating developmental hemostasis through proteomics may lead to more personalized medicine for hospitalized children.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Proteínas Sanguíneas / Proteômica / Hemostasia Limite: Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged / Newborn Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Envelhecimento / Proteínas Sanguíneas / Proteômica / Hemostasia Limite: Adult / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged / Newborn Idioma: En Ano de publicação: 2020 Tipo de documento: Article