Palladium catalyzed asymmetric allylic alkylation of isoquinolinedione derivatives in the preparation of quaternary carbon stereocenters.
Org Biomol Chem
; 18(24): 4551-4555, 2020 06 24.
Article
em En
| MEDLINE
| ID: mdl-32484497
ABSTRACT
A highly enantioselective allylic alkylation of isoquinolinedione derivatives under palladium catalysis was developed in the preparation of quaternary carbon stereocenters. Under standard reaction conditions, excellent yields and enantioselectivities were realized and the products could be transformed into dihydroisoquinolone with vicinal chiral carbon centers or THIQ core structures in short steps with high yields.
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MEDLINE
Idioma:
En
Ano de publicação:
2020
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Article