An Alternatively Spliced Sirtuin 2 Isoform 5 Inhibits Hepatitis B Virus Replication from cccDNA by Repressing Epigenetic Modifications Made by Histone Lysine Methyltransferases.

Piracha, Zahra Zahid; Saeed, Umar; Kim, Jumi; Kwon, Hyeonjoong; Chwae, Yong-Joon; Lee, Hyun Woong; Lim, Jin Hong; Park, Sun; Shin, Ho-Joon; Kim, Kyongmin

Piracha, Zahra Zahid; Saeed, Umar; Kim, Jumi; Kwon, Hyeonjoong; Chwae, Yong-Joon; Lee, Hyun Woong; Lim, Jin Hong; Park, Sun; Shin, Ho-Joon; Kim, Kyongmin.

Afiliação

Piracha ZZ; Department of Microbiology, Ajou University School of Medicine, Suwon, South Korea.
Saeed U; Department of Biomedical Science, Graduate School of Ajou University, Suwon, South Korea.
Kim J; Department of Microbiology, Ajou University School of Medicine, Suwon, South Korea.
Kwon H; Department of Biomedical Science, Graduate School of Ajou University, Suwon, South Korea.
Chwae YJ; Department of Microbiology, Ajou University School of Medicine, Suwon, South Korea.
Lee HW; Department of Biomedical Science, Graduate School of Ajou University, Suwon, South Korea.
Lim JH; Department of Microbiology, Ajou University School of Medicine, Suwon, South Korea.
Park S; Department of Biomedical Science, Graduate School of Ajou University, Suwon, South Korea.
Shin HJ; Department of Microbiology, Ajou University School of Medicine, Suwon, South Korea.
Kim K; Department of Biomedical Science, Graduate School of Ajou University, Suwon, South Korea.

J Virol ; 94(16)2020 07 30.

Article em En | MEDLINE | ID: mdl-32493816

Assuntos

DNA Circular/genética; Vírus da Hepatite B/fisiologia; Histona-Lisina N-Metiltransferase/genética; Sirtuína 2/genética; Replicação Viral/genética; Processamento Alternativo; Linhagem Celular Tumoral; DNA Circular/metabolismo; DNA Viral/genética; DNA Viral/metabolismo; Epigênese Genética; Repressão Epigenética; Hepatite B/virologia; Vírus da Hepatite B/genética; Vírus da Hepatite B/crescimento & desenvolvimento; Histona-Lisina N-Metiltransferase/metabolismo; Histonas/metabolismo; Humanos; Isoformas de Proteínas; Sirtuína 2/metabolismo; Transcrição Gênica; Ativação Transcricional

Palavras-chave

Sirt2 isoform 5; cccDNA; epigenetic modifications; hepatitis B virus; histone lysine methyltransferases

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Replicação Viral / DNA Circular / Vírus da Hepatite B / Histona-Lisina N-Metiltransferase / Sirtuína 2 Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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