Measuring Lipolytic Activity to Support Process Improvements to Manage Lipase-Mediated Polysorbate Degradation.

Jahn, Michael; Zerr, Andreas; Fedorowicz, Filip Maciej; Brigger, Finn; Koulov, Atanas; Mahler, Hanns-Christian

Jahn, Michael; Zerr, Andreas; Fedorowicz, Filip Maciej; Brigger, Finn; Koulov, Atanas; Mahler, Hanns-Christian.

Afiliação

Jahn M; Lonza AG, Drug Product Services, 60 A, CH-4057, Basel, Switzerland. michael.jahn@lonza.com.
Zerr A; Lonza AG, Drug Product Services, 60 A, CH-4057, Basel, Switzerland.
Fedorowicz FM; Lonza AG, Drug Product Services, 60 A, CH-4057, Basel, Switzerland.
Brigger F; Lonza AG, Drug Product Services, 60 A, CH-4057, Basel, Switzerland.
Koulov A; Lonza AG, Drug Product Services, 60 A, CH-4057, Basel, Switzerland.
Mahler HC; Lonza AG, Drug Product Services, 60 A, CH-4057, Basel, Switzerland.

Pharm Res ; 37(6): 118, 2020 Jun 03.

Article em En | MEDLINE | ID: mdl-32495187

Assuntos

Lipase/metabolismo; Lipólise; Polissorbatos/metabolismo; Animais; Hidrólise; Polissorbatos/química; Suínos

Palavras-chave

4-methylumbelliferone; degradation; fluorescence; lipase; polysorbate

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polissorbatos / Lipase / Lipólise Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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