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Bifunctional Naphtho[2,3-d][1,2,3]triazole-4,9-dione Compounds Exhibit Antitumor Effects In Vitro and In Vivo by Inhibiting Dihydroorotate Dehydrogenase and Inducing Reactive Oxygen Species Production.
Zuo, Zeping; Liu, Xiaocong; Qian, Xinying; Zeng, Ting; Sang, Na; Liu, Huan; Zhou, Yue; Tao, Lei; Zhou, Xia; Su, Na; Yu, Yamei; Chen, Qiang; Luo, Youfu; Zhao, Yinglan.
Afiliação
  • Zuo Z; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
  • Liu X; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
  • Qian X; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
  • Zeng T; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
  • Sang N; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
  • Liu H; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
  • Zhou Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
  • Tao L; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
  • Zhou X; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
  • Su N; Department of Pharmacy, West China Hospital, Sichuan University, Chengdu 610041, China.
  • Yu Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
  • Chen Q; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
  • Luo Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
  • Zhao Y; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China.
J Med Chem ; 63(14): 7633-7652, 2020 07 23.
Article em En | MEDLINE | ID: mdl-32496056
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triazóis / Naftoquinonas / Espécies Reativas de Oxigênio / Oxirredutases atuantes sobre Doadores de Grupo CH-CH / Inibidores Enzimáticos / Antineoplásicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triazóis / Naftoquinonas / Espécies Reativas de Oxigênio / Oxirredutases atuantes sobre Doadores de Grupo CH-CH / Inibidores Enzimáticos / Antineoplásicos Idioma: En Ano de publicação: 2020 Tipo de documento: Article