Successful Management of Glioblastoma Chemotherapy-Associated Dysgeusia with Gabapentin.
Can J Neurol Sci
; 47(6): 839-841, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-32498727
ABSTRACT
Dysgeusia is a frequent, yet underreported side effect of chemotherapy for cancer. We report here the first use of gabapentin in two glioblastoma patients who developed dysgeusia following intra-arterial administration of carboplatin or oral administration of lomustine, respectively. Treatment initiation was followed by resolution of taste alteration within weeks. Both patients reported significant improvement in their quality of life and regained weight, allowing further chemotherapy cycles. We hypothesized that in these two cases, chemotherapy impeded gustatory cells turnover and function, resulting in a gustatory "deafferentation-like" syndrome which was successfully addressed by the medication.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glioblastoma
/
Disgeusia
Tipo de estudo:
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article