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Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold.
Suebsuwong, Chalada; Dai, Bing; Pinkas, Daniel M; Duddupudi, Anantha Lakshmi; Li, Li; Bufton, Joshua C; Schlicher, Lisa; Gyrd-Hansen, Mads; Hu, Ming; Bullock, Alex N; Degterev, Alexei; Cuny, Gregory D.
Afiliação
  • Suebsuwong C; Department of Chemistry, University of Houston, Health Building 2, Houston, TX, 77204, USA.
  • Dai B; Department of Developmental, Molecular & Chemical Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, 02111, USA.
  • Pinkas DM; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7DQ, UK.
  • Duddupudi AL; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Health Building 2, Houston, TX, 77204, USA.
  • Li L; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Health Building 2, Houston, TX, 77204, USA.
  • Bufton JC; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7DQ, UK.
  • Schlicher L; Nuffield Department of Medicine, Ludwig Institute for Cancer Research, University of Oxford, Old Road Campus, Roosevelt Drive, OX3 7DQ, UK.
  • Gyrd-Hansen M; Nuffield Department of Medicine, Ludwig Institute for Cancer Research, University of Oxford, Old Road Campus, Roosevelt Drive, OX3 7DQ, UK.
  • Hu M; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Health Building 2, Houston, TX, 77204, USA.
  • Bullock AN; Structural Genomics Consortium, University of Oxford, Old Road Campus, Roosevelt Drive, Oxford, OX3 7DQ, UK.
  • Degterev A; Department of Developmental, Molecular & Chemical Biology, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA, 02111, USA. Electronic address: alexei.degterev@tufts.edu.
  • Cuny GD; Department of Pharmacological and Pharmaceutical Sciences, University of Houston, Health Building 2, Houston, TX, 77204, USA. Electronic address: gdcuny@central.uh.edu.
Eur J Med Chem ; 200: 112417, 2020 Aug 15.
Article em En | MEDLINE | ID: mdl-32505849
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proteína Serina-Treonina Quinase 2 de Interação com Receptor / Proteínas Adaptadoras de Sinalização NOD / Aminopiridinas Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Proteína Serina-Treonina Quinase 2 de Interação com Receptor / Proteínas Adaptadoras de Sinalização NOD / Aminopiridinas Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article