Follicle stimulating hormone, its association with glucose and lipid metabolism during the menopausal transition.
J Obstet Gynaecol Res
; 46(8): 1419-1424, 2020 Aug.
Article
em En
| MEDLINE
| ID: mdl-32510824
ABSTRACT
AIM:
Accumulative evidence shows that follicle stimulating hormone (FSH) is associated with metabolic disorders. We aimed to ascertain the relationship between FSH, blood glucose and lipid metabolism in general perimenopausal women.METHODS:
This cross-sectional study analyzed 2121 perimenopausal women aged 40-54 years in Zhejiang Province from January 2016 to December 2018. Regression analysis was performed to assess the relationship between FSH and metabolic parameters.RESULTS:
Serum FSH had a significant inverse association with fasting plasma glucose (P < 0.05) and triglycerides (TG) (P < 0.01) in perimenopausal women. However, after adjusting for body mass index, there was no significant association between FSH and fasting plasma glucose. In a model fully adjusted for demographic variables, estradiol, body mass index, high-density lipoprotein, low-density lipoprotein, homocysteine, systolic blood pressure and blood viscosity, a significant association still existed between FSH and TG (standardized ß = -0.095; R2 = 0.155; P = 0.002).CONCLUSION:
Overall, FSH is negatively associated with metabolic parameters, especially TG, in perimenopausal women. These results indicated that FSH might be a biomarker for the primary prevention of disorders with lipid metabolism during the menopausal period.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Metabolismo dos Lipídeos
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Hormônio Foliculoestimulante
Tipo de estudo:
Observational_studies
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Prevalence_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article