Synthetic dimeric-drug phospholipid: a versatile liposomal platform for cancer therapy.
Chem Commun (Camb)
; 56(55): 7621-7624, 2020 Jul 14.
Article
em En
| MEDLINE
| ID: mdl-32515754
ABSTRACT
An amphiphilic dimeric-podophyllotoxin (PODO) phospholipid was synthesized to assemble into liposomes as a combination of prodrug and nanocarrier. The results have demonstrated that the cell membrane-like delivery system possessed an improved cellular uptake and favorable antitumor efficacy with reduced side-effects. This strategy provides a new effective platform in drug delivery for cancer chemotherapy.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fosfatidilcolinas
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Podofilotoxina
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Lipossomos
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Neoplasias
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Antineoplásicos
Limite:
Animals
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Female
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Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article