Circulating extracellular vesicles from patients with valvular heart disease induce neutrophil chemotaxis via FOXO3a and the inhibiting role of dexmedetomidine.

Yuan, Hao-Xiang; Chen, Cai-Yun; Li, Yu-Quan; Ning, Da-Sheng; Li, Yan; Chen, Ya-Ting; Li, Shang-Xuan; Fu, Meng-Xia; Li, Xiao-Di; Ma, Jian; Jian, Yu-Peng; Liu, Dong-Hong; Mo, Zhi-Wei; Peng, Yue-Ming; Xu, Kang-Qing; Ou, Zhi-Jun; Ou, Jing-Song

Yuan, Hao-Xiang; Chen, Cai-Yun; Li, Yu-Quan; Ning, Da-Sheng; Li, Yan; Chen, Ya-Ting; Li, Shang-Xuan; Fu, Meng-Xia; Li, Xiao-Di; Ma, Jian; Jian, Yu-Peng; Liu, Dong-Hong; Mo, Zhi-Wei; Peng, Yue-Ming; Xu, Kang-Qing; Ou, Zhi-Jun; Ou, Jing-Song.

Afiliação

Yuan HX; Division of Cardiac Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Chen CY; National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Li YQ; NHC Key Laboratory of Assisted Circulation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Ning DS; Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Li Y; Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Chen YT; Division of Cardiac Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Li SX; National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Fu MX; NHC Key Laboratory of Assisted Circulation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Li XD; Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Ma J; Division of Cardiac Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Jian YP; National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Liu DH; NHC Key Laboratory of Assisted Circulation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Mo ZW; Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Peng YM; Division of Cardiac Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Xu KQ; National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Ou ZJ; NHC Key Laboratory of Assisted Circulation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.
Ou JS; Guangdong Provincial Engineering and Technology Center for Diagnosis and Treatment of Vascular Diseases, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China.

Am J Physiol Endocrinol Metab ; 319(1): E217-E231, 2020 07 01.

Article em En | MEDLINE | ID: mdl-32516026

Assuntos

Quimiotaxia de Leucócito/imunologia; Vesículas Extracelulares/imunologia; Doenças das Valvas Cardíacas/imunologia; Células Endoteliais da Veia Umbilical Humana/imunologia; Rim/imunologia; Neutrófilos/imunologia; Insuficiência Renal/imunologia; Agonistas de Receptores Adrenérgicos alfa 2/farmacologia; Adulto; Animais; Estudos de Casos e Controles; Quimiocina CCL5/efeitos dos fármacos; Quimiocina CCL5/imunologia; Quimiocina CCL5/metabolismo; Quimiotaxia de Leucócito/efeitos dos fármacos; Dexmedetomidina/farmacologia; Vesículas Extracelulares/efeitos dos fármacos; Vesículas Extracelulares/metabolismo; Feminino; Proteína Forkhead Box O3/efeitos dos fármacos; Proteína Forkhead Box O3/imunologia; Proteína Forkhead Box O3/metabolismo; Doenças das Valvas Cardíacas/metabolismo; Células Endoteliais da Veia Umbilical Humana/efeitos dos fármacos; Células Endoteliais da Veia Umbilical Humana/metabolismo; Humanos; Inflamação; Rim/efeitos dos fármacos; Rim/metabolismo; Masculino; Camundongos; Pessoa de Meia-Idade; Neutrófilos/efeitos dos fármacos; Fosforilação; Fator Plaquetário 4/efeitos dos fármacos; Fator Plaquetário 4/imunologia; Fator Plaquetário 4/metabolismo; Proteínas Proto-Oncogênicas c-akt/efeitos dos fármacos; Proteínas Proto-Oncogênicas c-akt/metabolismo; Insuficiência Renal/metabolismo; Vasodilatação

Palavras-chave

extracellular vesicles; forkhead box protein O3a; neutrophil chemotaxis; renal dysfunction; valvular heart surgery

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Quimiotaxia de Leucócito / Insuficiência Renal / Células Endoteliais da Veia Umbilical Humana / Vesículas Extracelulares / Doenças das Valvas Cardíacas / Rim / Neutrófilos Tipo de estudo: Observational_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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