Three new phomalone derivatives from a deep-sea-derived fungus Alternaria sp. MCCC 3A00467.
Nat Prod Res
; 36(1): 414-418, 2022 Jan.
Article
em En
| MEDLINE
| ID: mdl-32524853
ABSTRACT
Three new phomalone derivatives, phomalichenones E-G (1-3), and seven known analogues (4-10) were isolated from the cultures of a deep-sea-derived fungus Alternaria sp. MCCC 3A00467. Their structures were elucidated by spectroscopic methods, including the 1D and 2D NMR, and ECD spectrum. Among the compounds isolated, phomalichenone F (2) presented cytotoxic activity against human myeloma cancer U266 cells with IC50 value of 24.99 µg/mL. The most active compound, 10, showed cytotoxicity against U266, HepG2 and A549 cells with IC50 values of 13.26, 14.69 and 24.39 µg/mL, respectively.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Alternaria
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article