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Synthesis and Structure-Activity Relationships of 5'-Aryl-14-alkoxypyridomorphinans: Identification of a µ Opioid Receptor Agonist/δ Opioid Receptor Antagonist Ligand with Systemic Antinociceptive Activity and Diminished Opioid Side Effects.
Vekariya, Rakesh H; Lei, Wei; Ray, Abhisek; Saini, Surendra K; Zhang, Sixue; Molnar, Gabriella; Barlow, Deborah; Karlage, Kelly L; Bilsky, Edward J; Houseknecht, Karen L; Largent-Milnes, Tally M; Streicher, John M; Ananthan, Subramaniam.
Afiliação
  • Vekariya RH; Chemistry Department, Southern Research, Birmingham, Alabama 35205, United States.
  • Lei W; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, United States.
  • Ray A; Chemistry Department, Southern Research, Birmingham, Alabama 35205, United States.
  • Saini SK; Chemistry Department, Southern Research, Birmingham, Alabama 35205, United States.
  • Zhang S; Chemistry Department, Southern Research, Birmingham, Alabama 35205, United States.
  • Molnar G; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, United States.
  • Barlow D; Department of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, Maine 04005, United States.
  • Karlage KL; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, United States.
  • Bilsky EJ; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, United States.
  • Houseknecht KL; Department of Biomedical Sciences, College of Osteopathic Medicine, University of New England, Biddeford, Maine 04005, United States.
  • Largent-Milnes TM; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, United States.
  • Streicher JM; Department of Pharmacology, College of Medicine, University of Arizona, Tucson, Arizona 85724, United States.
  • Ananthan S; Chemistry Department, Southern Research, Birmingham, Alabama 35205, United States.
J Med Chem ; 63(14): 7663-7694, 2020 07 23.
Article em En | MEDLINE | ID: mdl-32530286
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Receptores Opioides delta / Receptores Opioides mu / Analgésicos Opioides / Morfinanos / Antagonistas de Entorpecentes Tipo de estudo: Diagnostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piridinas / Receptores Opioides delta / Receptores Opioides mu / Analgésicos Opioides / Morfinanos / Antagonistas de Entorpecentes Tipo de estudo: Diagnostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article